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Subject: [DCHAS-L] Assessing and predicting the health hazards of newly synthesized compounds for the development of SDSs.
Date: Monday, October 12, 2015 10:58:42 AM
Author: "Rupkey, Steve" <srupkey**At_Symbol_Here**ANL.GOV> 		Next by Date:
Subject: Re: [DCHAS-L] Assessing and predicting the health hazards of newly synthesized compounds for the development of SDSs.
Date: Tue, 13 Oct 2015 11:33:05 +0000
Author: Louis DiBerardinis

From: Alan Hall <ahalltoxic**At_Symbol_Here**GMAIL.COM>
Subject: Re: [DCHAS-L] Assessing and predicting the health hazards of newly synthesized compounds for the development of SDSs.
Date: Mon, 12 Oct 2015 15:55:36 -0500
Reply-To: DCHAS-L <DCHAS-L**At_Symbol_Here**MED.CORNELL.EDU>
Message-ID: CAHFAP+62SSWK0qij1aBXxNs0UB8FJVy6Y+8YTCL8Cw=jvjzTXQ**At_Symbol_Here**mail.gmail.com
In-Reply-To <71E50DF480EFA64BA856FD3CB7B11BE1ECCEFA08**At_Symbol_Here**BUTKUS.anl.gov>


There is a program developed by, if memory serves, ORISE and Oak Ridge Associated Universities that may address some of thjese concerns.

Alan
Alan H. Hall, M.D.
Medical Toxicologist

On Mon, Oct 12, 2015 at 9:58 AM, Rupkey, Steve <srupkey**At_Symbol_Here**anl.gov> wrote:

Greetings:

What do others do to assess, predict and assign an OSHA 2012 health hazard classification to a newly synthesize compound develop by your home institution when you are required to develop a SDS?

I'm not so concerned about assessing the hazards of mixtures of known chemicals but concerned more about new compounds, where the new compound has no history of a health hazard evaluation and where using the precursor chemicals is not as reliable predictor of its health hazards/toxicity.

Does anyone use a toxicologist to review the chemical structure of the new compound to predict and present their "best judgment" regarding the health hazard classifications?

Sincerely,

Steve Rupkey, CIH

Argonne National Laboratory

srupkey**At_Symbol_Here**anl.gov


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