About This Archive  | DCHAS-L 2015 Index   | DCHAS-L Yearly Index
person wearing a disposable face shield and surgical style mask

Check out Safety Emporium for your N95, N99, and face shield needs.

Previous by Date:
Subject: Re: [DCHAS-L] Accommodations for a service animal in the lab
Date: Tuesday, September 8, 2015 1:15:35 PM
Author: Monona Rossol <actsnyc**At_Symbol_Here**cs.com> 		Next by Date:
Subject: [DCHAS-L] EPA: two final reports on alternatives for flame retardants
Date: Tue, 8 Sep 2015 16:49:24 -0400
Author: "Secretary, ACS Division of Chemical Health and Safety"

From: "Stuart, Ralph" <Ralph.Stuart**At_Symbol_Here**keene.edu>
Subject: [DCHAS-L] Nat Academy of Sciences publication: Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense (2015)
Date: Tue, 8 Sep 2015 19:15:23 +0000
Reply-To: DCHAS-L <DCHAS-L**At_Symbol_Here**MED.CORNELL.EDU>
Message-ID: 7A623365-8DD2-42B9-83C3-B56D80846257**At_Symbol_Here**keene.edu


Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense (2015)
Free to download from:
https://urldefense.proofpoint.com/v2/url?u=http-3A__www.nap.edu_catalog_21775_application-2Dof-2Dmodern-2Dtoxicology-2Dapproaches-2Dfor-2Dpredicting-2Dacute-2Dtoxicity-2Dfor-2Dchemical-2Ddefense&d=BQIGaQ&c=lb62iw4YL4RFalcE2hQUQealT9-RXrryqt9KZX2qu2s&r=meWM1Buqv4IQ27AlK1OJRjcQl09S1Zta6YXKalY_Io0&m=L7Cn3dG3GtsyXxkiKBznFksQwpLTOOwPG0yP-86RyLo&s=pReeK-H7ImqLrSaXM3Mv0DX8atJCUj3rnrPQnUXclh0&e=

Authors
Committee on Predictive-Toxicology Approaches for Military Assessments of Acute Exposures; Board on Environmental Studies and Toxicology; Board on Life Sciences; Division on Earth and Life Studies; The National Academies of Sciences, Engineering, and Medicine

Description

The US Department of Defense (DOD) is faced with an overwhelming task in evaluating chemicals that could potentially pose a threat to its deployed personnel. There are over 84,000 registered chemicals, and testing them with traditional toxicity-testing methods is not feasible in terms of time or money. In recent years, there has been a concerted effort to develop new approaches to toxicity testing that incorporate advances in systems biology, toxicogenomics, bioinformatics, and computational toxicology. Given the advances, DOD asked the National Research Council to determine how DOD could use modern approaches for predicting chemical toxicity in its efforts to prevent debilitating, acute exposures to deployed personnel. This report provides an overall conceptual approach that DOD could use to develop a predictive toxicology system. Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense reviews the current state of computational and hig!
h-throughput approaches for predicting acute toxicity and suggests methods for integrating data and predictions. This report concludes with lessons learned from current high-throughput screening programs and suggests some initial steps for DOD investment.

Topics

‰?¢ Environment and Environmental Studies ‰?? Pollutants and Toxics
‰?¢ Conflict and Security Issues ‰?? Military and Defense Studies
Publication Info

Previous post   |  Top of Page   |   Next post


The content of this page reflects the personal opinion(s) of the author(s) only, not the American Chemical Society, ILPI, Safety Emporium, or any other party. Use of any information on this page is at the reader's own risk. Unauthorized reproduction of these materials is prohibited. Send questions/comments about the archive to secretary@dchas.org.
The maintenance and hosting of the DCHAS-L archive is provided through the generous support of Safety Emporium.