Melinda,
While you're waiting to get a taste of Harry's course, you might consider the last 10 years of Organic Syntheses, a series going back over 70 years. !0-20 years ago they began requiring safety discussions in all the preps accepted. They can provide your students with real world examples the students are likely to encounter in lab work in synthesis.
Since synthesis is exactly what the word means, many of the compounds and reactions are highly experimental, and may involve issues that have to be recognized and thought about. For that situation, textbooks and references like Bretherick's are not so useful. Intuition, hazard appreciation and recognition are invaluable, and are mostly learned with others through discussions. I encourage you to include researchers at your institution to come and talk about their work making never before made compounds by new methods.
I hope it goes well for you.
Lee Latimer
A 50+ year organic synthesis chemist.
-----Original Message-----
From: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Sent: Jan 13, 2022 1:41 PM
To: <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Subject: Re: [DCHAS-L] chemical reactivity - hazard evaluation
Melinda
I believe the Division's workshop on the chemical reactivity hazard, presented by Harry Elston, addresses a lot of this. It is on the schedule for the spring group of workshops.
Let me know if you have any questions.
Neal
From: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU> On Behalf Of Melinda Box
Sent: Thursday, January 13, 2022 11:38 AM
To: DCHAS-L**At_Symbol_Here**Princeton.EDU
Subject: [DCHAS-L] chemical reactivity - hazard evaluation
Hi, all,
I am reaching to get your idea, suggestions, and experiences with regard to reactivity hazard evaluation. I recently discovered how very unhelpful CAMEO and Bretherick's are for evaluating research in organic synthesis or even compounds involved in drug manufacturing and am wondering what other recommendations people might make for resources to include in a hazard evaluation curriculum being designed for undergraduate and graduate Chemistry researchers.
Thanks in advance for any input you might offer,
Melinda Box, MEd, CCHO
Organic Chemistry Lab Supervisor
North Carolina State University
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