Jack,
Several people have linked articles on explosives, but as a synthetic organic chemist I think that this article will resonate with your researchers. It is about safe synthesis at small scale of azide compounds and addresses techniques and testing.
https://pubs.acs.org/doi/abs/10.1021/acs.joc.8b00270
Craig
Craig A. Merlic
Professor of Chemistry, UCLA Department of Chemistry and Biochemistry
Executive Director, UC Center for Laboratory Safety
Los Angeles, CA 90095-1569
From: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU> on behalf of TILAK CHANDRA <0000058f112ac338-dmarc-request**At_Symbol_Here**LISTS.PRINCETON.EDU>
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Date: Tuesday, April 27, 2021 at 11:37 AM
To: <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Subject: Re: [DCHAS-L] Explosive synthesis scaleup question
Hi Rob,
A few more useful articles on explosive safety:
https://pubs.acs.org/doi/abs/10.1016/j.jchas.2014.01.001
https://pubs.acs.org/doi/abs/10.1016/j..jchas.2014.11.004
Scale-up from 100 mg to 5.0 g scale is not a prudent practice for explosive compounds.
Tilak
From: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU> on behalf of ILPI Support <info**At_Symbol_Here**ILPI.COM>
Sent: Tuesday, April 27, 2021 12:49 PM
To: DCHAS-L**At_Symbol_Here**Princeton.EDU <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Subject: Re: [DCHAS-L] Explosive synthesis scaleup question
Rob Toreki
Recently we had a researcher contact us with two questions: testing explosive properties of a novel compound, and scaling up from a 100 mg synthesis to (eventually, with intermediate steps) a 5 g synthesis. The compound in question is, as I mentioned, novel, but I believe the proper name would be iodomethyl diazirine. To our knowledge, we don't have anyone on campus with the equipment to do sensitivity tests or the like, so would anyone have guidance on finding appropriate facilities? Additionally, does anyone have experience with researchers doing syntheses with this sort of compound at this sort of scale? If so, what sort of facilities and equipment would you say are necessary to perform the synthesis safely? Additionally, do you know of any faculty whose labs work with diazirines in particular? Thank you!
Sincerely,
Research Safety Specialist, Assistant Chemical Hygiene Officer
Environmental Health & Safety
484 Oak Road, Stanford, CA, 94305
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