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Subject: Re: [DCHAS-L] Explosive synthesis scaleup question
Date: Tuesday, April 27, 2021 at 1:49:06 PM
Author: ILPI Support <info**At_Symbol_Here**ILPI.COM> 		Next by Date:
Subject: Re: [DCHAS-L] Explosive synthesis scaleup question
Date: Tue, 27 Apr 2021 18:38:53 +0000
Author: Luis P Barthel-Rosa

From: TILAK CHANDRA <0000058f112ac338-dmarc-request**At_Symbol_Here**LISTS.PRINCETON.EDU>
Subject: Re: [DCHAS-L] Explosive synthesis scaleup question
Date: Tue, 27 Apr 2021 18:05:58 +0000
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Message-ID: CH2PR06MB66144032611A568CBE4E77E988419**At_Symbol_Here**CH2PR06MB6614.namprd06.prod.outlook.com
In-Reply-To


Hi Rob,


A few more useful articles on explosive safety:


https://pubs.acs.org/doi/abs/10.1016/j.jchas.2014.01.001

https://pubs.acs.org/doi/abs/10.1016/j.jchas.2014.11.004


Scale-up from 100 mg to 5.0 g scale is not a prudent practice for explosive compounds.


Tilak

From: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU> on behalf of ILPI Support <info**At_Symbol_Here**ILPI.COM>
Sent: Tuesday, April 27, 2021 12:49 PM
To: DCHAS-L**At_Symbol_Here**Princeton.EDU <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Subject: Re: [DCHAS-L] Explosive synthesis scaleup question
 
I would make the researcher sit down and read the CSB case file on the Texas Tech incident before doing anything else. https://www.csb.gov/texas-tech-university-chemistry-lab-explosion/ 

See the references 3 through 10 here for assessment and testing methods: https://pubs.acs.org/doi/10.1021/acs.oprd.9b00422 

Rob Toreki


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On Apr 27, 2021, at 1:24 PM, Jack Reidy <jreidy2**At_Symbol_Here**STANFORD.EDU> wrote:

All,
 
Recently we had a researcher contact us with two questions: testing explosive properties of a novel compound, and scaling up from a 100 mg synthesis to (eventually, with intermediate steps) a 5 g synthesis. The compound in question is, as I mentioned, novel, but I believe the proper name would be iodomethyl diazirine. To our knowledge, we don't have anyone on campus with the equipment to do sensitivity tests or the like, so would anyone have guidance on finding appropriate facilities? Additionally, does anyone have experience with researchers doing syntheses with this sort of compound at this sort of scale? If so, what sort of facilities and equipment would you say are necessary to perform the synthesis safely? Additionally, do you know of any faculty whose labs work with diazirines in particular? Thank you!

Sincerely,
 
Jack Reidy (he/him)
Research Safety Specialist, Assistant Chemical Hygiene Officer
Environmental Health & Safety
Stanford University
484 Oak Road, Stanford, CA, 94305
Tel: (650) 497-7614
 
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