Good morning,You might want to compare SDS sheets with Chemwatch SDS. The SDS from Chemwatch says to treat skin contact with calcium gluconate gel. That's a red flag that we need to have calcium gluconate gel handy and signs posted warning people of the hazard. I am new to safety but I feel that this method is helping me catch things like this.Which safety data sheet should we trust?Best,Jerry FrancoTTU Chemistry DSOFrom: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU> On Behalf Of TILAK CHANDRA
Sent: Tuesday, March 30, 2021 9:48 AM
To: DCHAS-L**At_Symbol_Here**Princeton.EDU
Subject: Re: [DCHAS-L] Tetrabutylammonium Fluoride-Nasty, but Not Nasty Like HF?I will recommend conducting a SciFinder search on the substrate when using TBAF as a reagent for a chemical transformation. There will be a huge difference in reactivity between HF and TBAF with different substrates. Anhydrous TBAF behaves not only as a potent source of nucleophilic fluoride but also as a potent base.The following recent safety articles can be sources for the students to design the experiments and find suitable safety information when using the TBAF for chemical manipulations.Good luck.Tilak
From: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU> on behalf of Margaret Rakas <mrakas**At_Symbol_Here**SMITH.EDU>
Sent: Monday, March 29, 2021 2:32 PM
To: DCHAS-L**At_Symbol_Here**Princeton.EDU <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Subject: [DCHAS-L] Tetrabutylammonium Fluoride-Nasty, but Not Nasty Like HF?Hi all-We have a student project for advanced synthesis whose design include tetrabutylammonium fluoride (20-30%) in THF.. The SDS from the vendor, a large, trusted chem/bio supply company, plus checking on PubChem, indicates that while this is a corrosive (especially to eyes) and a health hazard, there is not the warning text that accompanies hydrofluoric acid or even ammonium fluoride-no indication for treatment with calcium gluconate gel.Now I trust this company's SDS but given it's a fluoride compound, checked what I could and found corroboration of the hazard but no first aid requiring calcium gluconate. Can anyone explain why this material isn't quite as bad as HF or ammonium fluoride? Is it hindrance in penetrating bone from the tetrabutyl group or the low-ish percentage of the tetrabutylammonium fluoride in the solution or ???thank you all!
Margaret--Margaret A. Rakas, Ph.D.
Lab Safety & Compliance Director
Clark Science Center
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