On Feb 6, 2019, at 11:42 AM, Monona Rossol <0000030664c37427-dmarc-request**At_Symbol_Here**LISTS.PRINCETON.EDU> wrote:

Alan,

Maybe squatters should not move in next door to a chemical plant?

Can't believe you said this.  Go see.

And the lawsuits filed after and even still today have to do with continuing health issues and sensitization.  So this is another problem that won't go away until the last Bhopal victim, and perhaps their fist generation children are dead and gone.

Monona

-----Original Message-----
From: Alan Hall <oldeddoc**At_Symbol_Here**GMAIL.COM>
To: DCHAS-L <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Sent: Wed, Feb 6, 2019 1:02 pm
Subject: Re: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)

Et al,

In general (not necessarily speccific to the compound in question), most isocyanurates are sensitizers.  This means that a single high-level airborne exposure can cause RADS (Reactive Airways Dysfunction Syndrome) or in others with more low-level chronic exposure, Occupational Asthma (there are specific published critera for this diagnosis), and there's a few who don't any meet all of the criteria and still are disabled.

That whole disaster in Bhopal was with MIC. I've had to review every bit of the data. It causes pulmonary edema which was fatal in many cases.  There was no cyanide release.  Maybe squatters should not move in next door to a chemical plant?  It was there first.  But a true tragedy and if a couple disgruntled employees had not done the wrong thing, it mght never have happened and the world would be a better place.

Free medical advice is worth exactly what you pay for it, but if I had worn your mocassins and walked a mile, I think I'd consult the folks at the Johns Hopkins in Baltimore and go from there.  Sir Osler founded the bedside teaching of medicine in America, and there's some darned good folks still there. There's some tests might done and maybe an improved treatment regimen.

Alan

Alan H. Hall, M.D.

Medical Toxicologist

Toxicology Consulting and Medical Translating Services

Springtown and Azle, Texas

Clinical Assistant Professor

Colorado School of Public Health

University of Colorado-Denver

On Wed, Feb 6, 2019 at 9:30 AM TILAK CHANDRA <0000058f112ac338-dmarc-request**At_Symbol_Here**lists.princeton.edu> wrote:

Isocyanates are also precursor for many pesticides. Methyl isocyanate (MIC) killed around 10,000 people in Bhopal in 1984 (Union carbide incident). It means some of the isocyanate can be lethal.

 

Tilak

 

From: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU> On Behalf Of Monona Rossol
Sent: Tuesday, February 05, 2019 1:56 PM
To: DCHAS-L**At_Symbol_Here**PRINCETON.EDU
Subject: Re: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)

 

Of course it is.  We need to look at adopting the UK rules for this whole bunch of chemicals.  They don't care what isocyanate radical is attached to, it is regulated as a sensitizer whether it has actually been tested and found so or not.  

Monona Rossol, MS, MFA, Industrial Hygienist 

 

-----Original Message-----
From: Wisnewski, Adam <adam.wisnewski**At_Symbol_Here**YALE.EDU>
To: DCHAS-L <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Sent: Tue, Feb 5, 2019 2:47 pm
Subject: Re: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)

Here is a case series report JACI in Practice...It is a sensitizer 

 

https://www.ncbi.nlm.nih.gov/pubmed/30075342

 

Adam V Wisnewski, PhD

Senior Research Scientist 

Department Internal Medicine/Section General Medicine

Program in Occupational & Environmental Medicine

Yale School of Medicine

300 Cedar Street/PO Box 208057

Building: TACS420

New Haven, CT 06520-8057

203-737-4054 (lab)

203-645-5665 (cell)

 

---

From: Bello, Dhimiter <Dhimiter_Bello**At_Symbol_Here**uml.edu>
Sent: Tuesday, February 5, 2019 1:52 PM
To: Redlich, Carrie; Wisnewski, Adam
Subject: Fwd: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)

 

This was on my draft folder-

FYI

 

Sent from my iPhone

Please excuse typos and brevity.

Begin forwarded message:

From: Boitumelo Kgarebe <bkgarebe**At_Symbol_Here**GMAIL.COM>
Date: September 17, 2018 at 8:44:00 AM EDT
To: <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Subject: Re: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>

Dear Colleagues,

Our Occupational Medicine clinic saw two patients who were from the same company, performing the same duties, namely powder spray coating using a chemical called triglycidyl isocyanurate (TGIC).  They were  assessed and the clinic seemed convinced that this chemical is a sensitizer, causing their occupational condition.   

A factory visit to understand exposures and associated occupational setting well, was also undertaken .  The process observed was similar to what is described in literature. 

The Factory Management seems to be keen that we investigate this further, as they are adamant this chemical is not the likely cause of their respiratory (asthmatic) effects. Another point from the company is that the TGIC is actually bound to a resin thus not  active on its own as it is already in a bound state (not freely available).   

My question is: Is TGIC found in the sample/ that they use is freely available as a sensitiser? Are there other less harmful substitutes?

BVK

Dr Boitumelo V.  Kgarebe Phd(London) FAAS

Head: Analytical Services

25 Hospital Street, JHB 2001

National Institute for Occupational Health

National Health Laboratory Service

Tel: +27(0)11 712 6410   |  Mobile: +27(0)82 | Fax: +27(0) 712 6545

boitumelo.kgarebe**At_Symbol_Here**nioh.nhls.ac.za |  www.nioh.ac.za   | www.nhls.ac.za

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