From: "Robert H. Hill, Jr." <roberth_hill**At_Symbol_Here**mindspring.com>
Subject: Re: [DCHAS-L] Papers on risks of scaling up reactions
Date: Tue, 25 Sep 2018 12:23:52 -0400
Reply-To: "Robert H. Hill, Jr." <roberth_hill**At_Symbol_Here**mindspring.com>
Message-ID: 902578011.6065.1537892632831**At_Symbol_Here**wamui-boogie.atl.sa.earthlink.net


There is a short section on "Scale of work" in Bretherick's Vol 2, 7th edition, p. 369-70.  Perhaps related are Runaway Reactions in Bretherick's Vol 2, p.366-7 (see also Laboratory Safety for Chemistry Students, Section 5.3.10, p5-342 - 5-347).  

Good luck,  Bob Hill

-----Original Message-----
From: Samuella Beth Sigmann
Sent: Sep 25, 2018 11:38 AM
To: DCHAS-L**At_Symbol_Here**PRINCETON.EDU
Subject: Re: [DCHAS-L] Papers on risks of scaling up reactions

You could use the Texas Tech incident that the CSB investigated.

https://www.csb.gov/texas-tech-university-chemistry-lab-explosion/
Sammye


On 9/25/2018 11:04 AM, Jeffrey R. Cogswell wrote:

Hello

I'm currently working on a safety talk about RAMP and decided to include a section on "RAMPing up Reactions"

It was discussed at ACS that scaling up reactions is a under-stated danger in many chemistry laboratories.

 

Does anyone have any suggestion for articles that talks about or quantifies the risks of increasing the yield in chemical reactions?

 

For example: https://ac.els-cdn.com/S1871553213006178/1-s2.0-S1871553213006178-main.pdf?_tid=672cf49d-0170-4ff1-8b06-85bc88bda807&acdnat=1537887055_4baf3ea46cec9ef7b4cb51c2aba76bf8 I found very informative and it would be great to find more sources.

 

Thanks

 

Jeffrey R. Cogswell, Ph.D.

Chemical Inventory and Laboratory Resource Center Technician, EHS

37 Dewey Field Road, HB 6216

Hanover, New Hampshire 03755

http://www.dartmouth.edu/~ehs/

 

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We, the willing, led by the unknowing, are doing the impossible for the ungrateful. We have done so much, for so long, with so little, we are now qualified to do everything with nothing. Teresa Arnold paraphrased from Konstantin Josef Jire=C4=8Dek (1854 =E2=80" 1918)

 

Samuella B. Sigmann, MS, NRCC-CHO

Senior Lecturer/Safety Committee Chair/Director of Stockroom

A. R. Smith Department of Chemistry

Appalachian State University

525 Rivers Street

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Phone: 828 262 2755

Fax: 828 262 6558

Email: sigmannsb**At_Symbol_Here**appstate.edu

 

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Robert H. Hill, Jr., Ph.D.

Stone Mountain, GA 30087

roberth_hill**At_Symbol_Here**mindspring.com

 

"The Safety Ethic: I value safety, teach safety, work safely, prevent at-risk behavior, promote safety, and accept responsibility for safety." 



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