I believe that you mean Volatile Organic Compounds (VOC) analysis by GC/MS. A GC/MS analysis, whether it is in air, water/soil, etc. is an airtight system and will not pull in lab interference. You will not be able to tune the MS consistently if you have air leaks and will end up burning out your source if you run with air leaks. That being said, you will need venting of the system at the outlet inside the lab.
Vivian
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