Sandhya:
Extending the remarks of Eugene, a classic disease syndrome encountered in agriculture is Silo Fillers disease. When corn and other plant material ferments in a confined silo NO2 is formed. There is both an acute phase to the illness, including death, and a chronic phase that is not as well characterized. I remain convinced that a friend of mine who died in his mid- 60s with a diagnosis of idiopathic pulmonary fibrosis actually died as a result of residual injury traceable to multiple exposures to NO2 as a teenager growing up on a farm in the mid west.
I assume the investigators have a well written protocol (reviewed and approved by you) including a description of the containment system for the experimental apparatus.
Roger Subject: Re: [DCHAS-L] Safety Precautions for high concentrations of NO2 gas. Sandhya NO2 can cause delayed pulmonary edema, the effects may be delayed up to 72 hrs. The NO2 also causes rapid olfactory fatigue, similar to H2S. Leak testing of the system and gas monitoring is critical You should have the ATSDR Medical Treatment Guides available for ER http://www.atsdr.cdc.gov/mmg/Index.asp Eugene Ngai Chemically Speaking LLC From: DCHAS-L Discussion List [mailto:dchas-l**At_Symbol_Here**med.cornell.edu] On Behalf Of Sandhya Muralidharan Dear All, We have a laboratory planning to run experiments with high concentrations of NO2 gas[2500-5000 ppm]. Please advise on any specific specific safety precautions. Thanks, Sandhya -- Sandhya Muralidharan, PhD Laboratory Safety Specialist Environmental Health & Safety Stony Brook University New York email - sandhya.muralidharan**At_Symbol_Here**stonybrook.edu
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On Mon, 8/1/16, Eugene Ngai
To: DCHAS-L**At_Symbol_Here**MED.CORNELL.EDU
Date: Monday, August 1, 2016, 9:48 AM
Sent: Monday, August 1, 2016 12:11 PM
To: DCHAS-L**At_Symbol_Here**MED.CORNELL.EDU
Subject: [DCHAS-L] Safety Precautions for high concentrations of NO2 gas.