Hello Nadia,
I’ve recently had to research this due to working with some highly potent cancer drugs. There is a company called Safebridge Consulting (http://www.safebridge.com/ )that
has put out some good info on dealing with potent and ultrpotent compounds.. They even have a Potent Compound Safety Bootcamp. You can find a good article on their system for working with compounds using an Occupational Exposure Banding system in the Journal
of Chemical Health and Safety, July/ August 2005.
There was also a very helpful slideshow that I found, but I can only seem to get a partial link. The slideshow is Introduction to Containment of Potent Compounds. Here is a link to the search I found it on
http://www.google.com/webhp?nord=1#nord=1&q=Containment+Technology+Forum+2007+INTRODUCTION+TO+CONTAINMENT
It’s the first non-sponsored result.
I hope these help,
-Brady
Brady P. Arnold
EHS Officer
XenoTech, LLC
phone (913) 227-7143
fax (913) 227-7199
barnold**At_Symbol_Here**xenotechllc.com
From: DCHAS-L Discussion List [mailto:dchas-l**At_Symbol_Here**MED.CORNELL.EDU]
On Behalf Of Nadejda Spassova
Sent: Tuesday, February 11, 2014 8:33 AM
To: DCHAS-L**At_Symbol_Here**MED.CORNELL.EDU
Subject: [DCHAS-L] Clarification on : working with a high potency compound
Hi everybody,
Here is the clarification regarding my question : ‘’Working with a high potent compound’’
I am working in a pharmaceutical company and what I mean by high potency is very, very active compound (in that case active pharmaceutical ingredient = API) in the human body for the intended pharmacological
effect. This generic drug that we will work on in the near future has a daily dosage of only 20
=B5g per day (for that reason I guess it was classified as high potent drug) compare to a low potent drug e.g. 20g per day.
On the other side the LD 50 (mouse) of this compound is 200mg per kg, so it is not very toxic.
Sorry about this misunderstanding and thanks to all of you for the efforts trying to answer my not clear enough question,
Regards,
Nadia
Nadejda Spassova, Ph.D
Research Scientist II, R&D
T 514.366.7950ext. 270
F 514.366.5665
9321, Airlie Street, LaSalle, Quebec, Canada H8R 2B2
delmarchem.com
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