Kim Stone, MPH, CCHO
Senior Manager Health, Safety & Environment
sanofi-aventis Research Center
2090 E. Innovation Park Drive 85755
520 544-5821
Fax 520 575-8283
Hi Don,
I have seen TFA exposures and they never were as significant as this one is reported to be.
I believe they made the mixture themselves from the pure reagents.
I’m sure you are right that good protocols for handling corrosives should be protective. From the description of this incident, it seems the addition of long gauntlets and perhaps sleeve protectors would be warranted.
Thanks,
-Russ
Russell Vernon, Ph.D.
Research Safety
Environmental Health & Safety
University of California, Riverside
900 University Ave
Riverside, CA 92521
russell.vernon**At_Symbol_Here**ucr.edu
Direct (951) 827-5119
Admin (951) 827-5528
Fax (951) 827-5122
From: DCHAS-L
Discussion
List [mailto:DCHAS-L**At_Symbol_Here**list.uvm.edu] On Behalf Of Don
Abramowitz
Sent: Friday, September 24, 2010 7:23
AM
To:
DCHAS-L**At_Symbol_Here**LIST.UVM.EDU
Subject: Re: [DCHAS-L] BOC clevage safety
protocols
Seems
to me the injury was primarily a function of the TFA (trifluoroacetic
acid),
which is a pretty aggressive corrosive material. I
would think
generic protocols for handling corrosives would be applicable.
My
questions are: To what extent do users understand what's in the
cocktail? If the mixture has a name of its own, does awareness of
its
hazardous properties get lost along the
way?
&
nbsp;
Don
Donald
Abramowitz
Environmental Health & Safety Officer
Bryn Mawr
College
Bryn Mawr, PA
My first question is: where was the PPE?
As for a written protocol, I would include working within a VBE
(vent. balance enclosure), gloves and safety glasses...
I am certain others here have more feedback...
Sincerely,
george
George D. McCallion
Chemist III
Chemical Process Research & Development
Johnson Matthey Pharmaceutical Materials
2003 Nolte Drive
West Deptford, NJ 08066-1742
Voice: 856.384.7255
Fax: 856.384.7186
E-Mail: medchem**At_Symbol_Here**comcast.net
************************************************** **********************
*********
On Sep 23, 2010, at 9:38 PM, Russell Vernon wrote:
> Dear Fellow Chemists,
>
> A researcher at one of our sister campuses was using a needless
> syringe filled with a solution of 36 mL TFA, 2 mL thioanisole, 1.2
> mL ethane dithiol, and 0.8 mL anisole, She inadvertently expelled a
> portion which impacted her elbow. She very quickly washed the
> exposure with copious water. The skin became seriously discolored
> and it is likely the treatment will include skin grafts.
>
> This isn’t my area of expertise but from what I read it is a common
> protecting group cleavage cocktail for protein synthesis.
>
> If any of you have any written procedures that would improve the
> process we would appreciate getting a copy.
>
> Sincerely,
> -Russ
>
>
> Russell Vernon, Ph.D.
> Research Safety
> Environmental Health & Safety
> University of California, Riverside
> 900 University Ave
> Riverside, CA 92521
> www.ehs.ucr.edu
> russell.vernon**At_Symbol_Here**ucr.edu
>
> Direct (951) 827-5119
> Admin (951) 827-5528
> Fax (951) 827-5122
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