Date: Fri, 24 Sep 2010 07:11:17 -0700
Reply-To: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
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From: Russell Vernon <russell.vernon**At_Symbol_Here**UCR.EDU>
Subject: Re: BOC clevage safety protocols
In-Reply-To: <F189536A-6A56-4C0A-9A98-EE38CE25A6A3**At_Symbol_Here**comcast.net>
Good question George,
I didn't fill in all the facts...
The gloves she wore did not extend to the elbow. The material in fact
dribbled from her gloves to her arm.
She was wearing eye protection as well and I believe she as working in a
fume hood but I'll have to verify that.
-Russ

Russell Vernon, Ph.D.
Research Safety
Environmental Health & Safety
University of California, Riverside
900 University Ave
Riverside, CA 92521
www.ehs.ucr.edu
russell.vernon**At_Symbol_Here**ucr.edu

Direct (951) 827-5119
Admin (951) 827-5528
Fax (951) 827-5122

-----Original Message-----
From: DCHAS-L Discussion List [mailto:DCHAS-L**At_Symbol_Here**list.uvm.edu] On Behalf Of
George D. McCallion
Sent: Friday, September 24, 2010 2:42 AM
To: DCHAS-L**At_Symbol_Here**LIST.UVM.EDU
Subject: Re: [DCHAS-L] BOC clevage safety protocols

My first question is: where was the PPE?

As for a written protocol, I would include working within a VBE  
(vent. balance enclosure), gloves and safety glasses...

I am certain others here have more feedback...

Sincerely,
george

George D. McCallion
Chemist III
Chemical Process Research & Development
Johnson Matthey Pharmaceutical Materials
2003 Nolte Drive
West Deptford, NJ 08066-1742
Voice: 856.384.7255
Fax: 856.384.7186
E-Mail: medchem**At_Symbol_Here**comcast.net
************************************************************************ 
*********

On Sep 23, 2010, at 9:38 PM, Russell Vernon wrote:

> Dear Fellow Chemists,
>
> A researcher at one of our sister campuses was using a needless  
> syringe filled with a solution of 36 mL TFA, 2 mL thioanisole, 1.2  
> mL ethane dithiol, and 0.8 mL anisole, She inadvertently expelled a  
> portion which impacted her elbow. She very quickly washed the  
> exposure with copious water. The skin became seriously discolored  
> and it is likely the treatment will include skin grafts.
>
> This isn't my area of expertise but from what I read it is a common  
> protecting group cleavage cocktail for protein synthesis.
>
> If any of you have any written procedures that would improve the  
> process we would appreciate getting a copy.
>
> Sincerely,
> -Russ
>
>
> Russell Vernon, Ph.D.
> Research Safety
> Environmental Health & Safety
> University of California, Riverside
> 900 University Ave
> Riverside, CA 92521
> www.ehs.ucr.edu
> russell.vernon**At_Symbol_Here**ucr.edu
>
> Direct (951) 827-5119
> Admin (951) 827-5528
> Fax (951) 827-5122

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