A question from our University Vet with regard to an animal care protocol: Can you clarify whether lipopolysaccharide (LPS) should be classified as a toxic material? The MSDS I found on-line says: Health and Toxicity Hazard: In 20 gram mice, the LD50 of lipopolysaccharides ranges between 250- 500 µg by i.v. or i.p. administration. The LD50 in humans has not been determined. Lipopolysaccharides are highly pyrogenic. The minimal pyrogenic dose in humans following i.v. administration has been estimated at 4 ng/kg. Toxicological properties of lipopolysaccharides have not been fully investigated. They may be harmful by ingestion, inhalation or absorption through skin. From http://www.listlabs.com/MSDS/201,203,225.htm It sounds like a low LD50 to me, but perhaps someone on the list has a more informed perspective? - Ralph Ralph Stuart, CIH Environmental Safety Manager University of Vermont Environmental Safety Facility 667 Spear St. Burlington, VT 05405 rstuart**At_Symbol_Here**uvm.edu fax: (802)656-5407
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